Spatial Proteomics
Opto-proteomics
Proximity proteomics methods in the Bio-ID class are useful but they lack precision targeting, meaning control over where and when labeling occurs. We built a labeling strategy that offers exquisite spatio-temporal control over subcellular protein targeting. The best part? Labels are directly detected, not inferred like conventional proximity methods. Built upon the Syncell two-photon labeling platform, our strategy is vastly more sensitive. Help us advance this new technology in exciting new directions!
Deep Visual Proteomics
Deep visual proteomics (DVP) allows us to subsample the heterogeneity of complex tissue and explore how cellular context influences function. Combined with ultra-sensitive and rapid DIA-based proteomics on our Astral platforms, we can profile rare cell types and explore interesting niches. We have ideas for multiplexing, a current bottleneck of the DVP technology.