https://www.structurems.ca/blog daily 0.75 2023-11-21 https://www.structurems.ca/blog/blog-post-title-one-dmnp2 monthly 0.5 2022-03-04 https://www.structurems.ca/home daily 1.0 2026-05-27 https://www.structurems.ca/academic-research daily 0.75 2026-05-27 https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/2adea07c-b550-4c31-9c59-4e156f38ae7e/F1.png Structural Proteomics - HX-MS² Hydrogen-deuterium exchange is a structural method that monitors the dynamics of proteins. The method supports the analysis of protein-protein and protein-drug interactions and the measurement of protein stability. But it could be so much more if the technology was more sensitive, complexity tolerant and faster. Tandem MS provides this capability. We are advancing some exciting technology and software to make this a high-throughput ultrasensitive assay. https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/fd64da2c-3b06-42d1-8388-0ee408d04461/in+situ.png Structural Proteomics - In situ XL-MS Crosslinkers are “molecular rulers” that can return actual distance measurements. If we can install these crosslinkers in cells at high yield we can vastly improve our measurements of the cellular interactome. We figured out how. However, detecting them is another matter. Our research program in this area focuses on how to improve crosslink identification by mass spec, through new reagents, methods and software. https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/05ab9c3a-a628-4726-aa1a-e092e7bd0889/GraphicalAbstract.png Structural Proteomics - xTAP-MS Our latest crosslinking method. It should be possible to detect crosslinks for your complex of interest and support integrative modeling. Unfortunately, direct affinity isolation rarely works. Enter xTAP-MS, a method for detecting abundant crosslinks on targeted complexes. It works because it addresses the signal splitting phenomenon, but we still need to turn the strategy in to a universal and scalable solution. https://www.structurems.ca/team daily 0.75 2026-05-27 https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/1f62eed7-97d9-41ea-b6d2-7cfb23d94922/headshot-a.jpg https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/6f895894-2326-401c-8c6c-3ab052023f0a/Picture7.jpg https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/00beb1ef-4b02-4aa0-8217-753478827a76/IMG_20220228_140722.jpg https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/b9067670-736b-4563-8bf2-a39b243bdf32/morgan.jpg https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/ff55a2da-d6b8-4b5f-af03-95d0c87fc6bd/Pauline.jpg https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/d17c2e06-9e57-44be-8cf6-229fa940ab3f/Ben.jpg https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/bacd2844-2e4b-4ce8-9e8d-21c147a0d527/alex.jpg https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/6cef528e-7493-405b-bf7f-539e3b147128/IMG_4293.png https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/6cef528e-7493-405b-bf7f-539e3b147128/IMG_4293.png https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/6cef528e-7493-405b-bf7f-539e3b147128/IMG_4293.png https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/6cef528e-7493-405b-bf7f-539e3b147128/IMG_4293.png https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/03946083-189a-4fcc-b5b5-16f71121ea3e/alumni.png https://www.structurems.ca/facilities daily 0.75 2026-05-27 https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/62f646c5-95a5-4a9d-9192-f76bb8563d81/20260527_110223.jpg https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/48e0d8ea-0a27-45f7-bc5c-d514eacb537d/20260527_110258.jpg https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/6e0d648e-535b-4632-a7e4-b05d1e2bac42/20260527_110246.jpg https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/2111d467-2c41-4e90-acdb-2d50e8210f8d/20260527_110235.jpg https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/80d99639-70aa-4106-82f5-e2e7c30f8adc/2025-03-18+15.17.25.jpg https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/3532e2d2-d57e-4e25-b1f5-6b8c146c9c6b/2025-03-18+15.17.28.jpg https://www.structurems.ca/contact-us daily 0.75 2023-12-12 https://www.structurems.ca/service daily 0.75 2026-05-27 https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/a96fdd26-8f91-4c72-8d76-a9863d2d6b9f/source-detail.jpg https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/325e55e3-6d58-4e72-ad7c-df270b9099ff/Interaction.png https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/cde3576a-74fc-4c8a-86fe-27def431b989/pal-detail-narrow.jpg https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/b1f2da50-db58-4eea-b2d1-f424a87f335e/Science_Exchange_Logo.jpg https://www.structurems.ca/software daily 0.75 2026-05-27 https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/d89f81b5-cf8d-4a19-86aa-b99a55e55fcb/Picture10.png https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/38ef5f00-b4f0-4ecb-a87e-71ffb6a92161/riddell.png https://www.structurems.ca/spatialproteomics daily 0.75 2026-05-27 https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/0e59a8da-cd67-428e-857b-2d2d76ee799d/opto.png Spatial Proteomics - Opto-proteomics Proximity proteomics methods in the Bio-ID class are useful but they lack precision targeting, meaning control over where and when labeling occurs. We built a labeling strategy that offers exquisite spatio-temporal control over subcellular protein targeting. The best part? Labels are directly detected, not inferred like conventional proximity methods. Built upon the Syncell two-photon labeling platform, our strategy is vastly more sensitive. Help us advance this new technology in exciting new directions! https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/c857f7ef-49d3-445f-9178-dda30c948130/DVP.png Spatial Proteomics - Deep Visual Proteomics Deep visual proteomics (DVP) allows us to subsample the heterogeneity of complex tissue and explore how cellular context influences function. Combined with ultra-sensitive and rapid DIA-based proteomics on our Astral platforms, we can profile rare cell types and explore interesting niches. We have ideas for multiplexing, a current bottleneck of the DVP technology. https://www.structurems.ca/trajan daily 0.75 2026-05-27 https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/82a8bf7b-b96e-4334-92d2-ef332328af93/corp.png https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/082b0444-78ad-4625-a1ae-c62016429e54/IMG-20250703-WA0000.jpg https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/0bd9fe43-a600-49f2-8f82-2f467aca9128/20180927_100230%5B1%5D.jpg https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/3ff5c33f-d514-40e3-a495-99b024bd6943/2022-09-24+11.59.19.jpg https://images.squarespace-cdn.com/content/v1/620f08c46253c919e6ab8e32/a9a08cfc-554a-4f86-b02f-ba87374b3b61/2024-03-20+13.55.00.jpg